This illustration was produced for the publication of the article Discovery of the first-efficacious A2AR negative allosteric modulators for high
adenosine cancer immunotherapies in the Journal of Medicinal Chemistry.

Inhibition of adenosine receptors on immune cells (A2AR) is an immunotherapeutic strategy designed to promote the immune response in the treatment of cancer cells. In order to develop a safe and effective therapy, this study focused on the discovery of a new negative allosteric modulator (NAM) that changes the structure of the receptor protein, thereby inhibiting it.

Role: Illustration

Commissioned by: Dr Margot Boujut – University of Geneva